Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures.Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix.We propose that this increased stiffness positively feeds back on the contractile activities of myofib
Targeting colorectal cancer with human anti-EGFR monoclonocal antibodies: focus on panitumumab
George P Kim, Axel GrotheyCollege of Medicine, Mayo ClinicAbstract: Hob The human anti-epidermal growth factor receptor (EGFR) monoclonal antibody, panitumumab, represents a significant advance in the treatment of colorectal cancer.The strategy to target this receptor is based on sound cancer biology demonstrating its essential role in colorectal c
The Necessity to Seal the Re-Entry Tears of Aortic Dissection After TEVAR: A Hemodynamic Indicator
Thoracic endovascular aortic repair (TEVAR) is a common treatment for Stanford type B aortic dissection (TBAD).However, re-entry tears might be found distal to the stented region which transports blood between the true and false lumens.Sealing the re-entry tears, especially for the thoracic tears, could further reduce blood perfusion to the false l
Protective role of native root-associated bacterial consortium against root-knot nematode infection in susceptible plants
Abstract Root-knot nematodes (RKNs) are a global menace to agricultural crop production.The role of root-associated microbes (RAMs) in plant protection against RKN infection remains unclear.Here we observe that cucumber (highly susceptible to Meloidogyne incognita) exhibits a consistently lower susceptibility to M.incognita in the presence of nativ